Analyzing protein circular dichroism spectra for accurate secondary structures
نویسندگان
چکیده
منابع مشابه
SOMCD: method for evaluating protein secondary structure from UV circular dichroism spectra.
This article presents SOMCD, an improved method for the evaluation of protein secondary structure from circular dichroism spectra, based on Kohonen's self-organizing maps (SOM). Protein circular dichroism (CD) spectra are used to train a SOM, which arranges the spectra on a two-dimensional map. Location in the map reflects the secondary structure composition of a protein. With SOMCD, the predic...
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A user-friendly website for the analysis of protein secondary structures from Circular Dichroism (CD) and Synchrotron Radiation Circular Dichroism (SRCD) spectra has been created.
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The estimation of protein secondary structure from circular dichroism spectra is described by a multivariate linear model with noise (Gauss-Markoff model). With this formalism the adequacy of the linear model is investigated, paying special attention to the estimation of the error in the secondary structure estimates. It is shown that the linear model is only adequate for the alpha-helix class....
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متن کاملComputation and analysis of protein circular dichroism spectra.
Introduction Circular dichroism (CD) is the most widely used form of chiroptical spectroscopy, spectroscopic techniques that utilize the differential interaction of molecules with left− and right−circularly polarized light. In the absence of a magnetic field, the molecule must be chiral to give rise to a difference in the interaction with the two types of circularly polarized light. The phenome...
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ژورنال
عنوان ژورنال: Proteins: Structure, Function, and Genetics
سال: 1999
ISSN: 0887-3585,1097-0134
DOI: 10.1002/(sici)1097-0134(19990515)35:3<307::aid-prot4>3.3.co;2-v